TargetMol

16F16

Product Code:
 
TAR-T35608
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35608-5mg5mg£850.00
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TAR-T35608-50mg50mg£1,661.00
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TAR-T35608-100mg100mg£2,079.00
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Further Information

Bioactivity:
16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal slices. It also reduces pyramidal neuron death induced by amyloid-β precursor protein (APP) in rat corticostriatal slices.
CAS:
922507-80-0
Formula:
C16H17ClN2O3
Molecular Weight:
320.8
Purity:
0.98
SMILES:
O=C(CCl)N1C(C(OC)=O)(C)C2=C(C(C=CC=C3)=C3N2)CC1

References

Hoffstrom, B.G., Kaplan, A., Letso, R., et al.Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteinsNat. Chem. Biol.6(12)900-906(2010)