TargetMol

CAY10722

Product Code:
 
TAR-T35822
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35822-5mg5mg£850.00
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Quantity:
TAR-T35822-50mg50mg£1,661.00
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Quantity:
TAR-T35822-100mg100mg£2,079.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.
CAS:
388086-13-3
Formula:
C21H14Cl2N2O2
Molecular Weight:
397.26
Purity:
0.98
SMILES:
Clc1ccc(-c2nc3cc(NC(=O)Cc4ccccc4)ccc3o2)c(Cl)c1