TargetMol

Migalastat hydrochloride

Product Code:
 
TAR-T12038
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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This product comes from: United States.
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Further Information

Bioactivity:
Migalastat hydrochloride is a potent and competitive α-galactosidase A (α-Gal A) inhibitor (human α-Gal A,IC50 of 0.04 μM ).
CAS:
75172-81-5
Formula:
C6H14ClNO4
Molecular Weight:
199.63
Purity:
0.98
SMILES:
Cl.OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O

References

1. Asano N, et al. In vitro inhibition and intracellular enhancement of lysosomal alpha-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives. Eur J Biochem. 2000 Jul;267(13):4179-86. 2. Ishii S, et al. Preclinical efficacy and safety of 1-deoxygalactonojirimycin in mice for Fabry disease. J Pharmacol Exp Ther. 2009 Mar;328(3):723-31. 3. Young-Gqamana B, et al. Migalastat HCl reduces globotriaosylsphingosine (lyso-Gb3) in Fabry transgenic mice and in the plasma of Fabry patients. PLoS One. 2013;8(3):e57631.