TargetMol

SR59230A hydrochloride

Product Code:
 
TAR-T13016L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating antagonist of β3-adrenergic receptor(IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively).
CAS:
1135278-41-9
Formula:
C21H28ClNO2
Molecular Weight:
361.91
Purity:
0.98
SMILES:
Cl.CCc1ccccc1OC[C@@H](O)CN[C@H]1CCCc2ccccc12

References

1. Nisoli E, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes.Mol Pharmacol. 1996 Jan;49(1):7-14. 2. Kanzler SA, et al. Involvement of ?3-adrenergic receptors in the control of food intake in rats.Braz J Med Biol Res. 2011 Nov;44(11):1141-7. 3. Bruno G, et al. ?3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation.Oncogene. 2020 Jan;39(2):368-384. 4. Bexis S, et al. Role of alpha 1- and beta 3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse. Br J Pharmacol. 2009 Sep;158(1):259-66.