TargetMol

BMS493

Product Code:
 
TAR-T14689
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 also could prevent retinoic acid-induced differentiation. BMS493 increases nuclear corepressor interaction with RARs[1][2].
CAS:
215030-90-3
Formula:
C29H24O2
Molecular Weight:
404.509
Pathway:
Metabolism
Purity:
0.98
SMILES:
CC1(C)CC=C(C#Cc2ccccc2)c2cc(C=Cc3ccc(cc3)C(O)=O)ccc12
Target:
Retinoid Receptor

References

1. Elgamal RM, et al. BMS 493 Modulates Retinoic Acid-Induced Differentiation During Expansion of Human Hematopoietic Progenitor Cells for Islet Regeneration. Stem Cells Dev. 2018 Aug 1;27(15):1062-1075. 2. Yu Z, et al. Apoptosis induced by atRA in MEPM cells is mediated through activation of caspase and RAR. Toxicol Sci. 2006 Feb;89(2):504-9.