TargetMol

Bz 423

Product Code:
 
TAR-T14846
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Bz 423 is a pro-apoptotic 1,4-benzodiazepine with selectivity for autoreactive lymphocytes and activates Bax and Bak.
CAS:
216691-95-1
Formula:
C27H21ClN2O2
Molecular Weight:
440.93
Pathway:
Apoptosis
Purity:
0.98
SMILES:
CN1c2ccc(Cl)cc2C(=NC(Cc2ccc3ccccc3c2)C1=O)c1ccc(O)cc1
Target:
BCL

References

1. Blatt NB, et al. Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochem Pharmacol. 2009 Oct 15;78(8):966-73. 2. Blatt NB, et al. Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax. Free Radic Biol Med. 2008 Nov 1;45(9):1232-42.