TargetMol

MRT00033659

Product Code:
 
TAR-T16141
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization.
CAS:
1401731-54-1
Formula:
C15H14N4O
Molecular Weight:
266.304
Purity:
0.98
SMILES:
CC(=O)Nc1cccc(c1)-c1cnc2[nH]nc(C)c2c1

References

1. Huart AS, et al. A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novelactivator of the p53 pathway. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5578-85.