TargetMol

EIPA

Product Code:
 
TAR-TQ0157
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-TQ0157-50mg50mgEnquire
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TAR-TQ0157-2mg2mg£94.00
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TAR-TQ0157-1mL1 mL * 10 mM (in DMSO)£126.00
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Further Information

Bioactivity:
EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
CAS:
1154-25-2
Formula:
C11H18ClN7O
Molecular Weight:
299.76
Pathway:
Membrane transporter/Ion channel
Purity:
0.9852
SMILES:
CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
Target:
Sodium Channel; TRP/TRPV Channel

References

Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis. Oncotarget. 2017 Feb 28;8(9):14748-14758. Dai XQ, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85. Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42(6):2418-2429. Wang C, Hu R, Wang T, et al.A bivalent ?-carboline derivative inhibits macropinocytosis-dependent entry of pseudorabies virus by targeting the kinase DYRK1A.Journal of Biological Chemistry.2023: 104605.