TargetMol

Thymohydroquinone

Product Code:
 
TAR-T35749
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35749-1mg1mg£389.00
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TAR-T35749-5mg5mg£850.00
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TAR-T35749-10mg10mg£1,107.00
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TAR-T35749-25mg25mg£1,637.00
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TAR-T35749-50mg50mg£2,175.00
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TAR-T35749-100mg100mg£2,906.00
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Further Information

Bioactivity:
Thymohydroquinone is a quinone that has been found in N. sativa seeds and has diverse biological activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl free radicals in a cell-free assay (IC50 = 2.4 μg/ml) and has a Trolox equivalent value of 2.6 in an oxygen radical absorbance capacity (ORAC) assay when used at concentrations ranging from 1.6 to 6.4 μg/ml.1 Thymohydroquinone inhibits growth of A2780, OVCAR-8, and CIS-A2780 ovarian cancer cells (IC50s = 3.1, 8.9, and 9.8 μM, respectively), as well as immortalized human ovarian epithelial cells (IC50 = 14 μM).2 It is also active against P. falciparum in vitro (IC50 = 15.9 μM).
CAS:
2217-60-9
Formula:
C10H14O2
Molecular Weight:
166.22
Pathway:
Metabolism|Immunology/Inflammation|oxidation-reduction|NF-κb
Purity:
0.98
SMILES:
CC(C)c1cc(O)c(C)cc1O
Target:
Reactive Oxygen Species|Antioxidant

References

Tesarova H, et al. Determination of oxygen radical absorbance capacity of black cumin (Nigella sativa) seed quinone compounds. Nat Prod Commun. 2011;6(2):213-216. Johnson-Ajinwo OR, et al. The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents. Bioorg Med Chem Lett. 2018;28(7):1219-1222. Ivankovic S, et al. The antitumor activity of thymoquinone and thymohydroquinone in vitro and in vivo. Exp Oncol. 2006;28(3):220-224.