Further Information
Alternate Names/Synonyms:
Natural Killer Cell Receptor 2B4; NK Cell Activation-inducing Ligand; NAIL; NKR2B4; SLAMF4
1.0mg/ml
32160000
liquid
50mM Sodium Phosphate pH 7.5, 100mM KCl, 150mM NaCl.
Avoid freeze/thaw cycles. Keep sterile.
Recombinant soluble human CD244.
Preservative Free
Monoclonal Antibody. Antibody ANC244.8 binds to recombinant CD244-muIg (#ANC-544-020) in EIA, and to cell surface CD244 on human PBL in FACS. ANC244.8 binds to a CD244 epitope that is distinct from the binding sites of clone ANC2B4/3B12 (#ANC-259-020). It blocks binding of clone C1.7. Isotype: Mouse IgG1kappa. Immunogen: Recombinant soluble human CD244. Applications: ELISA, FACS. 50mM Sodium Phosphate pH 7.5, 100mM KCl, 150mM NaCl. CD244 (2B4; SLAMF4) is a 66kDa member of the CD2/SLAM related receptor family (SRR). It is expressed on NK, T cell subsets, monocytes and eosinophils. It is expressed at high levels on leuikemia initiating cells, and plays a role in their proliferative potential. In mice there are two transcription variants, a long form and a short form of CD244 each of which have distinct signaling properties. In humans, only the long form is expressed. Decreased CD244 expression on monocytes of SLE patients correlated (negatively) with autoantibody titer. CD244 mediated function in immune response can vary greatly dependant on the context of its ligation.
Q9BZW8
Plastic Vial
CD244 (2B4; SLAMF4) is a 66kDa member of the CD2/SLAM related receptor family (SRR). It is expressed on NK, T cell subsets, monocytes and eosinophils. It is expressed at high levels on leuikemia initiating cells, and plays a role in their proliferative potential. In mice there are two transcription variants, a long form and a short form of CD244 each of which have distinct signaling properties. In humans, only the long form is expressed. Decreased CD244 expression on monocytes of SLE patients correlated (negatively) with autoantibody titer. CD244 mediated function in immune response can vary greatly dependant on the context of its ligation.
Antibody, Cancer, Immunology, Inflammation
Monoclonal Antibody
>95% (SDS-PAGE)
Purified from concentrated hybridoma tissue culture supernatant.
Antibody ANC244.8 binds to recombinant CD244-muIg (#ANC-544-020) in EIA, and to cell surface CD244 on human PBL in FACS. ANC244.8 binds to a CD244 epitope that is distinct from the binding sites of clone ANC2B4/3B12 (#ANC-259-020). It blocks binding of clone C1.7.
Non-hazardous
Primary Antibodies
12352203
Stable for at least 1 year after receipt when stored at +4A°C.