ANGPTL6 (human) ELISA Kit
Product Code:
AG-45A-0016Y
AG-45A-0016Y
Regulatory Status:
RUO
RUO
Target Species:
Human
Human
Application:
Enzyme-Linked Immunosorbent Assay (ELISA)
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
BLUE ICE
BLUE ICE
Storage:
Short term: +4°C. Long term: +4°C
Short term: +4°C. Long term: +4°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| AG-45A-0016YEK-KI01 | 96 wells | £600.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
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Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
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Further Information
Alternate Names/Synonyms:
Angiopoietin-like Protein 6; AGF; Angiopoietin-related Growth Factor
Assay Type:
Sandwich
Detection Type:
Colorimetric
EClass:
32160000
Handling Advice:
After standard reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Plate and reagents should reach room temperature before use.
Long Description:
ELISA Assay. Detects human ANGPTL6. Does not cross-react with human ANGPTL3, human ANGPTL4 or human ANGPTL7. Colorimetric assay. Sample Types: Cell Culture Supernatant, Plasma, Serum. Range: 1.56 to 100ng/ml. Sensitivity: 1.2ng/ml. Seven proteins containing an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristics of angiopoietins, have been identified and therefore designated angiopoietin-like proteins 1-7 (ANGPTL 1-7). ANGPTL3 and ANGPTL6 (Angiopoietin-related growth factor; AGF), among others, function to regulate angiogenesis and also appear to directly regulate lipid, glucose and energy metabolism. The serum levels of ANGPTL6 are significantly increased in obese humans, patients with type 2 diabetes mellitus (T2DM) and in metabolic syndrome. Therefore, ANGPTL6 may be a novel biomarker for metabolic diseases and may provide a novel therapeutic approach to counteract obesity, T2DM and insulin resistance.
NCBI, Uniprot Number:
Q8NI99
Package Type:
Box
Product Description:
Seven proteins containing an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristics of angiopoietins, have been identified and therefore designated angiopoietin-like proteins 1-7 (ANGPTL 1-7). ANGPTL3 and ANGPTL6 (Angiopoietin-related growth factor; AGF), among others, function to regulate angiogenesis and also appear to directly regulate lipid, glucose and energy metabolism. The serum levels of ANGPTL6 are significantly increased in obese humans, patients with type 2 diabetes mellitus (T2DM) and in metabolic syndrome. Therefore, ANGPTL6 may be a novel biomarker for metabolic diseases and may provide a novel therapeutic approach to counteract obesity, T2DM and insulin resistance.
Range:
1.56 to 100ng/ml
Sample Type:
Cell Culture Supernatant, Plasma, Serum
Sensitivity:
1.2ng/ml
Specificity:
Detects human ANGPTL6. Does not cross-react with human ANGPTL3, human ANGPTL4 or human ANGPTL7.
Transportation:
Non-hazardous
UNSPSC Category:
ELISA Kits
UNSPSC Number:
41116126
References
Serum levels of angiopoietin-related growth factor are increased in preeclampsia: H. Stepan, et al.; Am. J. Hypertens. 22, 314 (2009) | Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis: T. Ebert, et al.; Metabolism 58, 547 (2009) | Serum levels of angiopoietin-related growth factor are increased in metabolic syndrome: J. Namkung, et al.; Metabolism 60, 564 (2011) | Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery disease: E.B. Beck, et al.; Eur. J. Prev. Cardiol. 19, 412 (2012) | Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation: G. Flehmig, et al.; PLos One 9, e99785 (2014) | Adipokines may mediate the relationship between resting metabolic rates and bone mineral densities in obese women: S. Moradi, et al.; Osteopor. Int. 28, 1619 (2017) | Increased serum angiopoietin-like 6 ahead of metabolic syndrome in a prospective cohort study: J. Namkung, et al.; Diabetes Metab. J. 43, 521 (2019) | Serum Angiopoietin-like Protein 6, risk of type 2 diabetes, and response to hyperglycemia: A prospective cohort study: K.C. Fan, et al.; J. Clin. Endocrinol. Metab. 105, e1949 (2020)