Leinco Technologies

Human Eotaxin-3 ELISA Development Kit

Product Code:
 
LEI-E145
Product Group:
 
ELISA Kits
Host Type:
 
Human
Regulatory Status:
 
RUO
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
 
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LEI-E145-15plates15 plates£1,069.00
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Further Information

Long Description:
Eotaxin-3/CCL-26 belongs to a family of CC chemokines, which are potent chemoattractants for eosinophils that signal through the CCR3 receptor. 1 It is produced by endothelial cells stimulated with IL-4 or IL-13. Eotaxin-3 selectively targets cells expressing CCR3, including eosinophils, basophils, T cells and monocytes. It has been reported that eotaxin-3 is an antagonist for CCR2.2 Eotaxin-3 has similar activity to Eotaxin and Eotaxin-2, but the three Eotaxins share only a low degree of sequence homology. Eotaxin-3 is up-regulated in the context of a T helper 2 mediated inflammatory bowel disease via the signal transducer and activator of transcription 6, thus suggesting that the intestinal epithelium actively participates in the recruitment of eosinophils at the site of inflammation.1
Target:
Eotaxin-3

References

1. Cuber JC.et al. (2005) Int J Biochem Cell biol. 37: 2559 2. Gerber B. et al. (2004) J Biol Chem. 279: 23357