Leinco Technologies

Anti-Human Beta Site APP Cleaving Enzyme (CT) (BACE)

Product Code:
 
LEI-B362
Product Group:
 
Primary Antibodies
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
Ambient
Storage:
 
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
 

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CodeSizePrice
LEI-B362-20ug20 ug£221.00
Quantity:
LEI-B362-0.1mg0.1 mg£591.00
Quantity:
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Further Information

Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Formulation:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen:
PN:B365
Long Description:
Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer?s disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b- and g-sites by two proteases. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all suffers of Alzheimer?s disease. The long-sought b-secretase was recently identified by several groups independently and designated β-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2).1-4 BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
NCBI Gene:
23621
Target:
Beta Site APP Cleaving Enzyme

References

1. Vassar, R. et al. (1999) Science 286:735 2. Hussain, I. et al. (1999) Mol. Cell Neurosci. 14:419 3. Yan, R. et al. (1999) Nature 402:533 4. Sinha, S. et al. (1999) Nature 402:537