Elabscience

TRPM8 Polyclonal Antibody

Product Code:
 
E-AB-90427
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze/thaw cycles.
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Western blot analysis of extracts of various cell lines using TRPM8 Polyclonal Antibody at 1:3000 dilution.
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Western blot analysis of extracts of various cell lines using TRPM8 Polyclonal Antibody at 1:3000 dilution.

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CodeSizePrice
E-AB-90427-60uL60uL£210.00
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E-AB-90427-120uL120uL£291.00
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E-AB-90427-200uL200uL£431.00
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This product comes from: China.
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Further Information

Abbreviation:
TRPM8
Background:
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.
Buffer:
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Calculated MW:
5kDa/18kDa/79kDa/127kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant fusion protein of human TRPM8
ObservedMW:
122kDa
Purification method:
Affinity purification
Target Synonym:
TRPM8;LTRPC6;TRPP8
UNIProt ID:
Q7Z2W7

Documents