NSJ Bioreagents

ALDH1L1 Antibody

Product Code:
 
NSJ-V4987
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
ALDH1L1/7702
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
 
Aliquot the ALDH1L1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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IHC staining of FFPE human hepatocellular carcinoma tissue with ADH1L1 antibody (clone ALDH1L1/7702). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.~
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IHC staining of FFPE human colon
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IHC staining of FFPE human hepatocellular carcinoma tissue with ADH1L1 antibody (clone ALDH1L1/7702). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.~
IHC staining of FFPE human colon

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CodeSizePrice
NSJ-V4987-20UG20 ug£264.00
Quantity:
NSJ-V4987-100UG100 ug£534.00
Quantity:
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This product comes from: United States.
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Further Information

Application Details:
Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
Description:
Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH1L1 (aldehyde dehydrogenase 1 family member L1), also known as FTHFD or 10-FTHFD (10-formyltetrahydrofolate dehydrogenase), is a cytosolic protein that is developmentally regulated in the cerebellum. ALDH1L1 binds to folate and catalyzes the conversion of 10-formyltetrahydrofolate (10-FTHF) to tetrahydrofolate (THF). This suggests a possible role for ALDH1L1 in the regulation of cellular THF levels as well as in the inhibition of cell proliferation (as 10-FTHF is essential for the synthesis of purine). In addition, the overexpression of ALDH1L1 can restrict cell proliferation in vitro.
Format:
Purified
Formulation:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Immunogen:
A recombinant fragment of human ALDH1L1 protein was used as the immunogen for the ALDH1L1 antibody.
Limitation:
This ALDH1L1 antibody is available for research use only.
Localization:
Cytoplasm
Purity:
Protein A/G affinity
Uniprot #:
O75891

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