TargetMol

(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide

Product Code:
 
TAR-T14390L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T14390L-1mg1mg£227.00
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TAR-T14390L-5mg5mg£416.00
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TAR-T14390L-10mg10mg£581.00
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TAR-T14390L-25mg25mg£863.00
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TAR-T14390L-50mg50mg£1,163.00
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Further Information

Bioactivity:
(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist with an EC50 for Apelin receptors of 0.012 uM.(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5- methylpyrimidin-2-yl)butane-2-sulfonamide is used in the treatment of heart failure, atherosclerosis, obesity, diabetes mellitus, amyotrophic lateral sclerosis, coronary artery disease, hypertension, stroke and myocardial infarction.
CAS:
2049979-31-7
Formula:
C25H29N7O4S
Molecular Weight:
523.61
Pathway:
GPCR/G Protein
Purity:
0.9869
SMILES:
N(S([C@@H]([C@@H](C)C=1N=CC(C)=CN1)C)(=O)=O)C=2N(C(=NN2)C=3C=C(C)C=NC3)C4=C(OC)C=CC=C4OC
Target:
Apelin receptor

References

Chen, et al. Triazoles as agonists of the APJ receptor and their preparation. WO2016187308A1.