TargetMol

JAK/HDAC-IN-1

Product Code:
 
TAR-T15605
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T15605-1mg1mg£111.00
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TAR-T15605-5mg5mg£168.00
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TAR-T15605-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T15605-10mg10mg£230.00
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TAR-T15605-25mg25mg£374.00
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TAR-T15605-50mg50mg£528.00
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Quantity:
TAR-T15605-100mg100mg£728.00
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Further Information

Bioactivity:
JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor (IC50s: 4 and 2 nM for JAK2 and HDAC). It also shows antiproliferative and proapoptotic activities in several hematological cell lines.
CAS:
2284621-75-4
Formula:
C19H21Cl2N7O2
Molecular Weight:
450.32
Pathway:
JAK/STAT signaling|DNA Damage/DNA Repair|Tyrosine Kinase/Adaptors|Angiogenesis|Chromatin/Epigenetic|Stem Cells
Purity:
0.9805
SMILES:
ONC(CCCCCn1ncc(Nc(nc2)nc(Nc(cc3)ccc3Cl)c2Cl)c1)=O
Target:
Tyrosine Kinases|HDAC|JAK

References

Liang X, et al. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies. J Med Chem. 2019 Apr 25;62(8):3898-3923.