TargetMol

dBRD9 HCl

Product Code:
 
TAR-T31221L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
❮❯

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CodeSizePrice
TAR-T31221L-1mg1mg£229.00
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TAR-T31221L-5mg5mg£429.00
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TAR-T31221L-10mg10mg£650.00
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TAR-T31221L-25mg25mg£1,137.00
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TAR-T31221L-50mg50mg£1,557.00
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Quantity:
TAR-T31221L-100mg100mg£2,302.00
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Further Information

Bioactivity:
dBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . dBRD9 HCl is a potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). dBRD9 HCl does not degrade BRD4 or BRD7 at concentrations up to 5 uM. dBRD9 HCl displays antiproliferative effects in human AML cell lines.
CAS:
2341840-98-8
Molecular Weight:
856.75
Pathway:
Chromatin/Epigenetic
Purity:
0.9981
SMILES:
O=C1C2=C(C(C3=CC(OC)=C(CN(CC(NCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C)C(OC)=C3)=CN1C)C=CN=C2.Cl.Cl
Target:
Epigenetic Reader Domain

References

Remillard D, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743.