TargetMol

NM-3

Product Code:
 
TAR-T33701
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
❮❯

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CodeSizePrice
TAR-T33701-1mg1mg£223.00
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TAR-T33701-1mL1 mL * 10 mM (in DMSO)£422.00
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TAR-T33701-5mg5mg£456.00
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TAR-T33701-10mg10mg£622.00
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TAR-T33701-25mg25mg£938.00
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TAR-T33701-50mg50mg£1,259.00
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Quantity:
TAR-T33701-100mg100mg£1,669.00
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Quantity:
TAR-T33701-500mg500mg£3,219.00
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Further Information

Bioactivity:
NM-3 is an orally available anti-angiogenic inhibitor with anti-tumour activity.NM-3 is used as a radiation modulator in vitro and in vivo.NM-3 inhibits vascular endothelial growth factor (VEGF), thereby inhibiting the proliferation of endothelial cells. This inhibits the proliferation of endothelial cells. NM-3 is associated with a mechanism of apoptosis induction by reactive oxygen species.
CAS:
181427-78-1
Molecular Weight:
264.23
Pathway:
Metabolism|NF-κb|Immunology/Inflammation|Apoptosis
Purity:
0.9989
SMILES:
O=C1OC(=CC=2C=C(OC)C=C(O)C12)C(C(=O)O)C
Target:
Reactive Oxygen Species|Apoptosis

References

Salloum RM, et al. NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity. Cancer Res. 2000 ; 60(24):6958-6963. Agata N, et al. Suppression of type II collagen-induced arthritis by a new isocoumarin, NM-Res Commun Mol Pathol Pharmacol. 2000 ; 108(5-6):297-309. Zhu JS, et al. Molecule action mechanisms of NM-3 on human gastric cancer SGC-7901 cells in vivo or in vitro. World J Gastroenterol. 2003 ; 9(10):2366-2369. Yin L, et al. The novel isocoumarin 2-(8-hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl) propionic acid (NM-3) induces lethality of human carcinoma cells by generation of reactive oxygen species. Mol Cancer Ther. 2001 ; 1(1):43-48.