TargetMol

Laulimalide

Product Code:
 
TAR-T37063
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T37063-1mg1mgEnquire
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Further Information

Bioactivity:
Microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles.
CAS:
115268-43-4
Formula:
C30H42O7
Molecular Weight:
514.659
Purity:
0.98
SMILES:
[H][C@]12C[C@]([H])(OC(=O)\C=C\C[C@@]3([H])O[C@@]([H])(CC=C3)C[C@@H](C)CC(=C)C[C@H](O)[C@]1([H])O2)[C@@H](O)\C=C\[C@@H]1CC(C)=CCO1 |c:17,41,t:8|

References

Bennett et al (2012) Low-dose laulimalide represents a novel molecular probe for investigating microtubule organization. Cell Cycle. 11 3045 PMID:22871740 Pryor et al (2002) The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to PacT. and epothilones, and may not require its epoxide moiety for activity. Biochemistry. 41 9109 PMID:12119025 Bennett et al (2010) Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping. Chem.Biol. 17 725 PMID:20659685