TargetMol

1-(2-hydroxyethyl)-3-{4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl}urea

Product Code:
 
TAR-T67702
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67702-1mg1mg£352.00
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TAR-T67702-5mg5mg£736.00
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TAR-T67702-10mg10mg£978.00
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TAR-T67702-25mg25mg£1,348.00
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TAR-T67702-50mg50mg£1,661.00
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TAR-T67702-100mg100mg£2,079.00
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Quantity:
TAR-T67702-500mg500mg£4,006.00
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Further Information

Bioactivity:
1-(2-hydroxyethyl)-3-{4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl}urea is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia, skin cancer, breast cancer, lung cancer and colon cancer.
CAS:
1144075-38-6
Molecular Weight:
425.5
Pathway:
PI3K/Akt/mTOR signaling
Purity:
0.989
SMILES:
O=C(NC1=CC=C(C=C1)C2=NC=3C=CSC3C(=N2)N4CC5OC(C4)CC5)NCCO
Target:
PI3K|mTOR

References

Zask, et al. Preparation of thienopyrimidine and pyrazolopyrimidine compounds and their use as mTOR kinase and PI3 kinase inhibitors. US20090098086 A1. Verheijen JC, et al. Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett. 2010;20(1):375-379.