TargetMol

1-(2-fluoroethyl)-3-{4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl}urea

Product Code:
 
TAR-T67706
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67706-1mg1mg£335.00
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TAR-T67706-5mg5mg£711.00
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TAR-T67706-10mg10mg£946.00
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TAR-T67706-25mg25mg£1,396.00
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TAR-T67706-50mg50mg£1,862.00
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TAR-T67706-100mg100mg£2,424.00
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Further Information

Bioactivity:
1-(2-fluoroethyl)-3-{4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl}urea is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively.
CAS:
1144075-36-4
Molecular Weight:
427.5
Pathway:
PI3K/Akt/mTOR signaling
Purity:
0.9873
SMILES:
O=C(NC1=CC=C(C=C1)C2=NC=3C=CSC3C(=N2)N4CC5OC(C4)CC5)NCCF
Target:
PI3K|mTOR

References

Verheijen JC, Yu K, Toral-Barza L, Hollander I, Zask A. Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett. 2010 Jan 1;20(1):375-9.