TargetMol

HIF-2α agonist 2

Product Code:
 
TAR-T67831
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67831-1mg1mg£111.00
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TAR-T67831-5mg5mg£168.00
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TAR-T67831-10mg10mg£229.00
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TAR-T67831-25mg25mg£389.00
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TAR-T67831-50mg50mg£544.00
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TAR-T67831-100mg100mg£748.00
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TAR-T67831-500mg500mg£1,460.00
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Further Information

Bioactivity:
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 uM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structure of HIF-2a-ARNT complex without cytotoxicity to 786-o-Reha-Luc cells. HIF-2α agonist 2 can be used in the study of oxygen metabolism and is closely related to the occurrence of cancer.
CAS:
2750141-15-0
Molecular Weight:
416.09
Pathway:
Angiogenesis|Metabolism|Chromatin/Epigenetic
Purity:
0.9832
SMILES:
O=S1(=O)N=C(NC=2C=C(Br)C=C(Br)C2)C=3C=CC=CC31
Target:
HIF|HIF/HIF Prolyl-Hydroxylase

References

Yu Y, et al. Insight into the binding mode of HIF-2 agonists through molecular dynamic simulations and biological validation. Eur J Med Chem. 2021;211:112999.