TargetMol

GSK215

Product Code:
 
TAR-T67843
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67843-1mg1mg£173.00
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Quantity:
TAR-T67843-5mg5mg£325.00
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TAR-T67843-10mg10mg£470.00
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TAR-T67843-25mg25mg£736.00
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Quantity:
TAR-T67843-50mg50mg£994.00
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Quantity:
TAR-T67843-100mg100mg£1,315.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4). GSK215 is designed by the FAK inhibitor VS-4718 and a binder for the VHL E3 ligase. GSK215 can induce rapid and prolonged FAK degradation.
CAS:
2743427-26-9
Molecular Weight:
985.13
Pathway:
Cytoskeletal Signaling|Tyrosine Kinase/Adaptors|Angiogenesis
Purity:
0.993
SMILES:
N(C=1C(C(F)(F)F)=CN=C(NC2=C(OC)C=C(C=C2)N3CCN(CC(N[C@H](C(=O)N4[C@H](C(N[C@@H](C)C5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)C(C)(C)C)=O)CC3)C1)C7=C(C(NC)=O)C=CC=C7
Target:
FAK

References

Law RP, Nunes J, Chung CW, et al. Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs [published online ahead of print, 2021 Aug 20]. Angew Chem Int Ed Engl. 2021;10.1002/anie.202109237.