TargetMol

RBN-3143

Product Code:
 
TAR-T67844
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67844-1mg1mg£140.00
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TAR-T67844-5mg5mg£242.00
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TAR-T67844-1mL1 mL * 10 mM (in DMSO)£259.00
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TAR-T67844-10mg10mg£322.00
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TAR-T67844-25mg25mg£499.00
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TAR-T67844-50mg50mg£687.00
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TAR-T67844-100mg100mg£938.00
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TAR-T67844-500mg500mg£1,805.00
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Further Information

Bioactivity:
RBN-3143 is a potent and inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM). RBN-3143 inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14 in cell lines. RBN-3143 exhibits research potential of lung inflammation.
CAS:
2360853-16-1
Molecular Weight:
449.54
Pathway:
Chromatin/Epigenetic|DNA Damage/DNA Repair
Purity:
0.9864
SMILES:
O=C1N=C(NC2=CC(OCC3CCN(C(=O)C)CC3)=CC(F)=C12)CSC4CCOCC4
Target:
PARP

References

Niepel M, et, al. The PARP14 inhibitor RBN-3143 suppresses lung inflammation in preclinical models. European Respiratory Journal 2022 60: 4642.