TargetMol

MRT-2359

Product Code:
 
TAR-T67934
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67934-1mg1mg£189.00
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TAR-T67934-5mg5mg£369.00
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TAR-T67934-1mL1 mL * 10 mM (in DMSO)£418.00
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TAR-T67934-10mg10mg£517.00
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TAR-T67934-25mg25mg£790.00
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TAR-T67934-50mg50mg£1,050.00
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Quantity:
TAR-T67934-100mg100mg£1,396.00
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Quantity:
TAR-T67934-500mg500mg£2,713.00
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This product comes from: United States.
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Further Information

Bioactivity:
MRT-2359 is a potent and orally available GSPT1 reducer with antitumour activity.MRT-2359 inhibits the growth of drug-resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells.MRT-2359 exhibits preferential activity in MYC-driven cell lines.
CAS:
2803881-11-8
Molecular Weight:
495.38
Purity:
0.9825
SMILES:
O=C(OCC1=CC=C2C(=C1)C(=O)N(C2)C3C(=O)NC(=O)CC3)NC4=CC(OC(F)(F)F)=CC=C4F

References

Gerald Gavory, et al. Abstract 3449: Development of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for the treatment of lung cancers with MYC-induced translational addiction. Cancer Res. 2023 ; 83(7): 3449.