TargetMol

JB061

Product Code:
 
TAR-T67951
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67951-1mg1mg£97.00
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TAR-T67951-5mg5mg£132.00
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TAR-T67951-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T67951-10mg10mg£164.00
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TAR-T67951-25mg25mg£241.00
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TAR-T67951-50mg50mg£327.00
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TAR-T67951-100mg100mg£452.00
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TAR-T67951-500mg500mg£863.00
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This product comes from: United States.
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Further Information

Bioactivity:
JB061 is a nonmuscle myosin inhibitor with IC 50 s of 4.4 uM ( Cardiac muscle myosin ), 9.1 uM ( Skeletal muscle myosin ), and >100 uM ( Smooth muscle myosin II ), respectively. JB061 poorly decreases ATPase activity ( IC 50 >200 uM). JB061 shows cytotoxicity against COS-7 cells with an IC 50 value of 39 uM .
Molecular Weight:
323.34
Pathway:
Cytoskeletal Signaling
Purity:
0.9876
SMILES:
COc1cccc(C\N=C(/C)c2c(O)c3ccccc3oc2=O)c1
Target:
Myosin

References

Smith JD, et al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2023;247:115008.