TargetMol

Litoxetine HCl

Product Code:
 
TAR-T67956L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67956L-1mg1mg£149.00
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TAR-T67956L-1mL1 mL * 10 mM (in DMSO)£246.00
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TAR-T67956L-5mg5mg£254.00
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TAR-T67956L-10mg10mg£346.00
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TAR-T67956L-25mg25mg£541.00
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TAR-T67956L-50mg50mg£744.00
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TAR-T67956L-100mg100mg£1,002.00
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Further Information

Bioactivity:
Litoxetine HCl is a selective 5-hydroxytryptamine (5-HT) reuptake inhibitor (SSRI) and mixed 5-hydroxytryptamine antagonist used in the treatment of urinary incontinence. Litoxetine HCl in the absence of antimuscarinic concentrations without antimuscarinic properties (10 nM-1 microM) caused concentration-dependent relaxation of isolated oesophageal muscle mucosa in rats, reducing carbachol tone by up to 37%. Higher concentrations of Litoxetine HCl (3 microM-300 microM) were associated with significant relaxation up to abolition of carbachol tone. The antiarrhythmic activity of Litoxetine HCl, previously demonstrated in the isolated guinea pig intestine, was exerted in the isolated rat oesophageal muscle mucosa at concentrations greater than 1 microM. The 5-HT-releasing effect of Litoxetine HCl could explain the potency of Litoxetine HCl on 5-HT-induced relaxation in untreated rat tissue, which was reversed by pCPA treatment.
CAS:
T67956L
Molecular Weight:
277.79
Pathway:
GPCR/G Protein|Neuroscience
Purity:
0.9919
SMILES:
[H]Cl.C1(COC2CCNCC2)=CC3=C(C=CC=C3)C=C1
Target:
5-HT Receptor

References

Lucchelli A, et al. The interaction of antidepressant drugs with central and peripheral (enteric) 5-HT3 and 5-HT4 receptors. Br J Pharmacol. 1995 ; 114(5):1017-1025. Lucchelli A, et al. Influence of fluoxetine and litoxetine on 5-HT4 receptor-mediated relaxation in the rat isolated oesophagus. Fundam Clin Pharmacol. 1999 ; 13(3):330-336. Dmochowski RR, et al. A randomized, placebo-controlled clinical development program exploring the use of litoxetine for treating urinary incontinence. Neurourol Urodyn. 2021 ; 40(6):1515-1523. Fairweather DB, et al. The psychomotor and cognitive effects of litoxetine in young and middle aged volunteers. Br J Clin Pharmacol. 1995 ; 40(2):119-125.