TargetMol

Gliotoxin

Product Code:
 
TAR-TN1694
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TN1694-1mg1mg£197.00
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TAR-TN1694-5mg5mg£351.00
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Further Information

Bioactivity:
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis.
CAS:
67-99-2
Molecular Weight:
326.39
Pathway:
Apoptosis|Immunology/Inflammation|Microbiology/Virology|Neuroscience|Tyrosine Kinase/Adaptors|Stem Cells|Cytoskeletal Signaling|NF-κb
Purity:
0.98
SMILES:
CN([C@]1(CO)SS[C@@]2(CC([C@H]34)=CC=C[C@@H]4O)N3C1=O)C2=O
Target:
PKA|NF-κB|Apoptosis|COX|Antifection|Wnt/beta-catenin|Antibacterial

References

Schlam D, et al. Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis. MBio. 2016 Apr 5;7(2):e02242. Luo X, et al. Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. Nat Prod Res. 2017 Aug;31(16):1958-1962. Com?ra C, et al. Gliotoxin from Aspergillus fumigatus affects phagocytosis and the organization of the actin cytoskeleton by distinct signalling pathways in human neutrophils. Microbes Infect. 2007 Jan;9(1):47-54. Epub 2006 Dec 12. Zhang C, et al. Gliotoxin Induces Cofilin Phosphorylation to Promote Actin Cytoskeleton Dynamics and Internalization of Aspergillus fumigatus Into Type II Human Pneumocyte Cells. Front Microbiol. 2019 Jun 18;10:1345.