TargetMol

BODIPY FL VH032

Product Code:
 
TAR-T41171
Product Group:
 
Dyes, Stains, and Probes
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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TAR-T41171-5mg5mgEnquire
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Further Information

Bioactivity:
BODIPY FL VH032 is a high-affinity VHL fluorescent probe (Kd= 3.01 nM) with application in time-resolved fluorescence resonance energy-transfer (TR-FRET) assays for high-throughput identification and characterization of VHL ligands. BODIPY FL VH032 consists of a derivative of von Hippel-Lindau (VHL) ligand VH 032 and a fluorophore BODIPY FL(with excitation peak at 504 nm and emission peak at 520 nm), joined by a polyethylene glycol (PEG) 4 linker. The BODIPY FL VH032 VHL TR-FRET signal is stable through the 90 - 300 min incubation time, and theTR-FRET binding assay is sensitive, selective and resistant to assay interference. BODIPY FL VH032 also exhibits high VHL affinity in a fluorescence polarization (FP) assay. Excitation maximum ~ 504 nm; emission maximum ~ 520 nm.
Purity:
0.98

References

Lin et al (2020) Development of BODIPY FL VH032 as a high-affinity and selective von Hippel-Lindau E3 ligase. ACS Omega 6 680 PMID: 33458521