TargetMol

NLRP3/AIM2-IN-3

Product Code:
 
TAR-T60442
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T60442-5mg5mg£125.00
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TAR-T60442-1mL1 mL * 10 mM (in DMSO)£131.00
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TAR-T60442-10mg10mg£158.00
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TAR-T60442-25mg25mg£254.00
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TAR-T60442-50mg50mg£369.00
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TAR-T60442-100mg100mg£550.00
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Quantity:
TAR-T60442-500mg500mg£1,083.00
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Further Information

Bioactivity:
NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ? 0.008 u M. NLRP3/AIM2-IN-3 is a potent inhibitor of NLRP3 and AIM2 inflammasome-dependent cell lysis with an IC50 value for cell lysis of 0.077 ? 0.008 u M. NLRP3/AIM2-IN-3 inhibits LPS/nigericin NLRP3/AIM2-IN-3 inhibits LPS/nigericin-stimulated cell lysis in THP-1 macrophages with an IC50 value of 0.077 ? 0.008 uM. NLRP3/AIM2-IN-3 interferes with the interaction of NLRP3 or AIM2 with the bridging protein ASC, inhibiting oligomerization of ASC.
CAS:
1787787-60-3
Formula:
C16H14N2O2
Molecular Weight:
266.29
Pathway:
Immunology/Inflammation|NF-κb
Purity:
0.98
SMILES:
O=C(NC=1C=CC=C(O)C1)CC=2C=CC=3C=CNC3C2
Target:
NOD|AIM2

References

Jiao Y, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022;232:114194. Wang D, et al. Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells [published online ahead of print, 2023 Jul 27]. Phytomedicine. 2023;119:154998.