TargetMol

PCSK9-IN-11

Product Code:
 
TAR-T67776
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
❮❯

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CodeSizePrice
TAR-T67776-5mg5mg£108.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T67776-1mL1 mL * 10 mM (in DMSO)£128.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T67776-10mg10mg£135.00
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Quantity:
TAR-T67776-25mg25mg£201.00
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Quantity:
TAR-T67776-50mg50mg£282.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T67776-100mg100mg£401.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
PCSK9-IN-11 (compound 5r) is a potent PCSK9 inhibitor with oral activity. PCSK9-IN-11 shows inhibitory activity of PCSK9 transcription in HepG2 cells (IC50= 5.7 uM). PCSK9-IN-11 can increase LDL receptor (LDLR) protein level. PCSK9-IN-11 can be used for atherosclerosis research.
Molecular Weight:
381.79
Purity:
0.9837
SMILES:
CN1C(=O)C2=C(N=C(NCCO)N2CC2=C(F)C(Cl)=CC=C2)N(C)C1=O

References

Qiao MQ, et al. Structure-activity relationship and biological evaluation of xanthine derivatives as PCSK9 inhibitors for the treatment of atherosclerosis. Eur J Med Chem. 2022 Dec 26;247:115047.