TargetMol

TH1760

Product Code:
 
TAR-T67864
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67864-5mg5mg£111.00
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Quantity:
TAR-T67864-10mg10mg£143.00
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TAR-T67864-25mg25mg£239.00
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TAR-T67864-50mg50mg£390.00
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Quantity:
TAR-T67864-100mg100mg£546.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
TH1760 is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM). TH1760 can sensitize cells to 6-thioguanine by increasing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 can enhance the anti-leukemia effect of thiopurine.
CAS:
2567914-01-4
Molecular Weight:
426.45
Pathway:
Metabolism
Purity:
0.9703
SMILES:
O=C1OC2=CC(=CC=C2N1)S(=O)(=O)N3CCN(C(=O)C=4C=CC=5NC=CC5C4)CC3
Target:
NUDIX hydrolase

References

Zhang SM, et al. Development of a chemical probe against NUDT15. Nat Chem Biol. 2020 Oct;16(10):1120-1128. Rehling D, et al. Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity. J Biol Chem. 2021 Jan-Jun;296:100568.