TargetMol

I-138

Product Code:
 
TAR-T73560
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T73560-5mg5mg£404.00
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Quantity:
TAR-T73560-50mg50mg£1,821.00
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Quantity:
TAR-T73560-100mg100mg£2,319.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
I-138 is an orally active compound structurally related to ML323 . I-138 and ML-323 are potent reversible inhibitors of USP1-UAF1 . I-138 displays synergistic binding with ubiquitin and mutual exclusive binding with ML323. I-138 induces the monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increases PCNA and FANCD2 monoubiquitination in HAP-1 USP1 WT cells. I-138 ablates USP1 autocleavage in cells [1] .
CAS:
2098211-50-6
Formula:
C26H23F3N6O
Molecular Weight:
492.5
Purity:
0.98
SMILES:
O=C1NC2=CN=C(N=C2N1CC=3C=CC(=CC3)C4=NC(=CN4C)C(F)(F)F)C=5C=CC=CC5C(C)C