TargetMol

Bleomycin hydrochloride

Product Code:
 
TAR-T6116L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
❮❯

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CodeSizePrice
TAR-T6116L-10mg10mg£182.00
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This product comes from: United States.
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Further Information

Bioactivity:
Bleomycin hydrochloride is a potent antitumor antibiotic that functions as a DNA synthesis inhibitor and DNA damaging agent.
CAS:
67763-87-5
Molecular Weight:
1451.01
Pathway:
DNA Damage/DNA Repair|Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
C[C@H]([C@@H](C(NCCc1scc(c2scc(C(NCCC[S+](C)C)=O)n2)n1)=O)NC([C@H]([C@@H]([C@H](NC([C@H]([C@H](c3[nH]cnc3)O[C@@H]4O[C@H]([C@H]([C@@H]([C@@H]4O[C@H]5O[C@@H]([C@H]([C@@H]([C@@H]5O)OC(N)=O)O)CO)O)O)CO)NC(c6c(C)c(N)nc([C@@H](NC[C@@H](C(N)=O)N)CC(N)=O)n6)=O)=O)C)O)C)=O)O.[Cl-]
Target:
DNA/RNA Synthesis

References

Kang Miao, et al. Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis. Ther Adv Chronic Dis. 2020 Jul 30;11:2040622320940185. Corboz MR, et al. Therapeutic administration of inhaled INS1009, a LRX-15 prodrug formulation, inhibits bleomycin-induced pulmonary fibrosis in rats. Pulm Pharmacol Ther. 2018 Apr;49:95-103. Hovhannisyan G, et al. Comparative analysis of individual chromosome involvement in micronuclei induced by bleomycin in human leukocytes. Mol Cytogenet. 2016 Jun 21;9:49. Ling Peng, et al. Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-?B/NLRP3-mediated epithelial-mesenchymal transition and inflammation. Cell Death Dis. 2020 Nov 13;11(11):978. Jaaskela-Saari HA, et al. Squamous cell cancer cell lines: sensitivity to bleomycin and suitability for animal xenograft studies. Acta Otolaryngol Suppl. 1997;529:241-4.