TargetMol

Oxythiamine chloride HCl

Product Code:
 
TAR-T71783
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T71783-50mg50mg£97.00
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Quantity:
TAR-T71783-100mg100mg£111.00
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This product comes from: United States.
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Further Information

Bioactivity:
Oxythiamine chloride HCl is a thiamine antimetabolite that has anticancer activities. It is converted by thiamine pyrophosphokinase to oxythiamine pyrophosphate, a transketolase inhibitor. Oxythiamine decreases transketolase activity in breast cancer. It inhibits the nonoxidative synthesis of ribose and decreases RNA and DNA synthesis in pancreatic cancer. In vivo, oxythiamine induces cell cycle arrest at the G1 phase and apoptosis in an adenocarcinoma model. Oxythiamine, in combination with sorafenib, reduces tumor growth in an SMMC mouse xenograft model and has also been used to induce thiamine deficiency in mice.
CAS:
614-05-1
Molecular Weight:
338.25
Purity:
0.98
SMILES:
Cl.[Cl-].Cc1c(CCO)sc[n+]1Cc1cnc(C)nc1O