TargetMol

DM3

Product Code:
 
TAR-T11058
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1

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This product comes from: United States.
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Further Information

Bioactivity:
DM3 (Maytansinoid DM3) is a maytansine mimic containing disulfide or thiol groups and a tubulin inhibitor. It is the cytotoxic part of antibody-drug conjugates (ADCs) .
CAS:
796073-54-6
Formula:
C37H52ClN3O10S
Molecular Weight:
766.34
Purity:
0.98
SMILES:
C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC([C@@H](N(C(CCC(C)S)=O)C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]

References

Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).