TargetMol

4-Hydroxytolbutamide

Product Code:
 
TAR-T14040
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
4-Hydroxytolbutamide(Hydroxytolbutamide), a metabolite of Tolbutamide, which is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].
CAS:
5719-85-7
Formula:
C12H18N2O4S
Molecular Weight:
286.35
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
O=C(NCCCC)NS(=O)(=O)C1=CC=C(C=C1)CO
Target:
Potassium Channel

References

Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30(12):1311-9. Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21(6):664-71.