TargetMol

5-Hydroxylansoprazole

Product Code:
 
TAR-T14051
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole, a gastric proton-pump inhibitor that effectively treats various peptic diseases[1][2]. The metabolism of Lansoprazole occurs through CYP2C19, resulting in the formation of 5-Hydroxylansoprazole.
CAS:
131926-98-2
Formula:
C16H14F3N3O3S
Molecular Weight:
385.36
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
O=S(C1=NC=2C=C(O)C=CC2N1)CC3=NC=CC(OCC(F)(F)F)=C3C
Target:
Proton pump

References

Katar?na Kostolansk?, et al. Determination of lansoprazole, 5-hydroxylansoprazole, and lansoprazole sulfone in human plasma for CYP2C19 and CYP3A4 phenotyping. Chemical Papers. volume 73, pages2955?2963(2019). Xu HR, et al. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol. 2010 Aug;48(8):947-52. doi: 10.3109/13880200903300220.