TargetMol

PR-924

Product Code:
 
TAR-T16568
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
PR-924 is a selective inhibitor of tripeptide epoxyketone immunoproteasome subunit LMP-7 (IC50: 22 nM). PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities. PR-924 covalently modifies proteasomal N-terminal threonine active sites.
CAS:
1416709-79-9
Formula:
C37H38N4O5
Molecular Weight:
618.72
Pathway:
Proteases/Proteasome|Ubiquitination
Purity:
0.98
SMILES:
C([C@@H](C(N[C@H](C(=O)[C@@]1(C)CO1)CC2=CC=CC=C2)=O)NC([C@H](NC(=O)C=3CC=4C(C3C)=CC=CC4)C)=O)C=5C=6C(NC5)=CC=CC6
Target:
Proteasome

References

Parlati F, et al. Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood. 2009 Oct 15;114(16):3439-47. Singh AV, et al. PR-924, a selective inhibitor of the immunoproteasome subunit LMP-7, blocks multiple myeloma cell growth both in vitro and in vivo. Br J Haematol. 2011 Jan;152(2):155-63.