TargetMol

PROTAC BRD4-binding moiety 1

Product Code:
 
TAR-T18599
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand through a linker, enabling the formation of a PROTAC complex. This complex efficiently degrades BRD4[1].
CAS:
2101200-10-4
Molecular Weight:
371.43
Purity:
0.98
SMILES:
O=C1N(C2=CC=C(C=C2C(C=3C=CC=CC3)N1CC#C)C=4C(=NOC4C)C)C

References

Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.