TargetMol

PROTAC ERα Degrader-2

Product Code:
 
TAR-T18605
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 uM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
CAS:
1351169-29-3
Molecular Weight:
763.96
Purity:
0.98
SMILES:
C[C@@]1\2[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(CC/C2=N\OCC(NCCOCCOCCNC([C@@H](NC([C@H]([C@@H](CC5=CC=CC=C5)N)O)=O)CC(C)C)=O)=O)[H]

References

Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.