TargetMol

AP1867-2-(carboxymethoxy)

Product Code:
 
TAR-T18611
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules[1].
CAS:
2230613-03-1
Formula:
C38H47NO11
Molecular Weight:
693.78
Purity:
0.98
SMILES:
CC[C@H](C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1ccccc1OCC(O)=O)c1cc(OC)c(OC)c(OC)c1

References

Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441.