TargetMol

Thalidomide-O-amido-C4-NH2 hydrochloride

Product Code:
 
TAR-T18815
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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This product comes from: United States.
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Further Information

Bioactivity:
Thalidomide-O-amido-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that combines the cereblon ligand derived from Thalidomide with a linker. It is commonly employed in the synthesis of PROTACs[1].
CAS:
2245697-86-1
Molecular Weight:
438.86
Purity:
0.98
SMILES:
Cl.O=C(NCCCCN)COC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3

References

James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression.J Med Chem. 2018 Jan 25;61(2):462-481.