TargetMol

Casokefamide

Product Code:
 
TAR-T25206
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T25206-100mg100mgEnquire
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TAR-T25206-500mg500mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
Casokefamide is a peripherally-specific, synthetic opioid pentapeptide. It was derived from the β-casomorphin sequence and designed with the intention of improving resistance to digestive enzymes so that it could be used as an antidiarrheal medicine.
CAS:
98815-38-4
Molecular Weight:
632.71
Purity:
0.98
SMILES:
[C@H](CC1=CC=CC=C1)(C(N[C@@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(N)=O)=O)C)=O)NC([C@H](NC([C@H](CC3=CC=C(O)C=C3)N)=O)C)=O

References

Allescher HD, Storr M, Piller C, Brantl V, Schusdziarra V. Effect of opioid active therapeutics on the ascending reflex pathway in the rat ileum. Neuropeptides. 2000 Jun-Aug;34(3-4):181-6. PubMed PMID: 11021978. Fuglsang A, Nilsson D, Nyborg NC. Using spectrophotometry to determine in vitro turnover rates of peptides in plasma. J Biochem Biophys Methods. 2004 Feb 27;58(2):139-51. PubMed PMID: 14980787. Schulte-Frohlinde E, Reindl W, Bierling D, Lersch C, Brantl V, Teschemacher H, Schusdziarra V. Effects of oral casokefamide on plasma levels, tolerance, and intestinal transit in man. Peptides. 2000 Mar;21(3):439-42. PubMed PMID: 10793229. Brantl V, Picone D, Amodeo P, Temussi PA. Solution structure of casokefamide. Biochem Biophys Res Commun. 1993 Mar 31;191(3):853-9. PubMed PMID: 8466524.