TargetMol

SKF-107457

Product Code:
 
TAR-T26192
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T26192-100mg100mgEnquire
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TAR-T26192-500mg500mgEnquire
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Further Information

Bioactivity:
SKF-107457 is an HIV protease type 1 inhibitor. It is a hexapeptide substrate analog with the scissile bond being replaced by a hydroxy ethylene isostere.
CAS:
126333-28-6
Molecular Weight:
577.723
Purity:
0.98
SMILES:
COC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CC[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(C)C)C(C)C |@:35|

References

Verkhivker GM. Empirical free energy calculations of human immunodeficiency virus type 1 protease crystallographic complexes. II. Knowledge-based ligand-protein interaction potentials applied to thermodynamic analysis of hydrophobic mutations. Pac Symp Biocomput. 1996:638-52. PubMed PMID: 9390264. Zhao B, Winborne E, Minnich MD, Culp JS, Debouck C, Abdel-Meguid SS. Three-dimensional structure of a simian immunodeficiency virus protease/inhibitor complex. Implications for the design of human immunodeficiency virus type 1 and 2 protease inhibitors. Biochemistry. 1993 Dec 7;32(48):13054-60. PubMed PMID: 8241159. Murthy KH, Winborne EL, Minnich MD, Culp JS, Debouck C. The crystal structures at 2.2-A resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations. J Biol Chem. 1992 Nov 15;267(32):22770-8. PubMed PMID: 1429626. Wood SJ, Wetzel R. A novel method for the incorporation of glycoprotein-derived oligosaccharides into neoglycopeptides. Bioconjug Chem. 1992 Sep-Oct;3(5):391-6. PubMed PMID: 1420438.