TargetMol

ANNINE-6plus

Product Code:
 
TAR-T30078
Product Group:
 
Dyes, Stains, and Probes
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
ANNINE-6plus is a water soluble voltage sensitive dye (also called potentiometric dyes). This compound was developed at the Max Planck Institute for Biochemistry in Germany. It is used to optically measure the changes in transmembrane voltage of excitable cells, including neurons, skeletal and cardiac myocytes. ANNINE-6plus has a fractional fluorescent intensity change (δF/F per 100 mV change) of about 30% with single-photon excitation (~488 nm) and >50% with two-photon excitation (~1060 nm).
CAS:
1151942-85-6
Molecular Weight:
717.62
Purity:
0.98
SMILES:
C[N+](C)(C)CCC[N+]1=CC2=CC=C3C4=CC=C5C(C=CC6=CC(N(CCCC)CCCC)=CC=C56)=C4C=CC3=C2C=C1.[Br-].[Br-]

References

Ramamoorthy S, Wilson TM, Wu T, Nuttall AL. Non-uniform distribution of outer hair cell transmembrane potential induced by extracellular electric field. Biophys J. 2013 Dec 17;105(12):2666-75. doi: 10.1016/j.bpj.2013.11.021. PubMed PMID: 24359738; PubMed Central PMCID: PMC3882456. Wegner LH, Frey W, Sch?nw?lder S. A critical evaluation of whole cell patch clamp studies on electroporation using the voltage sensitive dye ANNINE-6. Bioelectrochemistry. 2013 Aug;92:42-6. doi: 10.1016/j.bioelechem.2013.03.002. Epub 2013 Apr 3. PubMed PMID: 23603150. Pag?s S, C?t? D, De Koninck P. Optophysiological approach to resolve neuronal action potentials with high spatial and temporal resolution in cultured neurons. Front Cell Neurosci. 2011 Oct 10;5:20. doi: 10.3389/fncel.2011.00020. eCollection 2011. PubMed PMID: 22016723; PubMed Central PMCID: PMC3191737. Vignali S, Peter N, Ceyhan G, Demir IE, Zeller F, Senseman D, Michel K, Schemann M. Recordings from human myenteric neurons using voltage-sensitive dyes. J Neurosci Methods. 2010 Oct 15;192(2):240-8. doi: 10.1016/j.jneumeth.2010.07.038. Epub 2010 Aug 5. PubMed PMID: 20691728.