TargetMol

Atromentin

Product Code:
 
TAR-T30204
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Atromentin is a natural chemical compound found in Agaricomycetes fungi in the orders Agaricales and Thelephorales. It can also be prepared by laboratory synthesis. Chemically, it is a polyphenol and a benzoquinone.
CAS:
519-67-5
Formula:
C18H12O6
Molecular Weight:
324.28
Purity:
0.98
SMILES:
O=C1C(O)=C(C(=O)C(O)=C1C=2C=CC(O)=CC2)C=3C=CC(O)=CC3

References

Geib E, Baldeweg F, Doerfer M, Nett M, Brock M. Cross-Chemistry Leads to Product Diversity from Atromentin Synthetases in Aspergilli from Section Nigri. Cell Chem Biol. 2019 Feb 21;26(2):223-234.e6. doi: 10.1016/j.chembiol.2018.10.021. Epub 2018 Dec 6. PubMed PMID: 30527997. Schneider P, Bouhired S, Hoffmeister D. Characterization of the atromentin biosynthesis genes and enzymes in the homobasidiomycete Tapinella panuoides. Fungal Genet Biol. 2008 Nov;45(11):1487-96. doi: 10.1016/j.fgb.2008.08.009. Epub 2008 Sep 6. PubMed PMID: 18805498. Kim JH, Lee CH. Atromentin-induced apoptosis in human leukemia U937 cells. J Microbiol Biotechnol. 2009 Sep;19(9):946-50. PubMed PMID: 19809251. Zheng CJ, Sohn MJ, Kim WG. Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae. J Antibiot (Tokyo). 2006 Dec;59(12):808-12. PubMed PMID: 17323650.