TargetMol

Deazaminopterin

Product Code:
 
TAR-T31269
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Deazaminopterin is a bioactive chemical.
CAS:
18921-68-1
Molecular Weight:
438.44
Purity:
0.98
SMILES:
NC=1C2=C(C=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=C2)N=C(N)N1

References

DeGraw JI, Christie PH, Tagawa H, Kisliuk RL, Gaumont Y, Schmid FA, Sirotnak FM. Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin. J Med Chem. 1986 Jun;29(6):1056-61. PubMed PMID: 3712374. Toner LE, Vrhovac R, Smith EA, Gardner J, Heaney M, Gonen M, Teruya-Feldstein J, Sirotnak F, O'Connor OA. The schedule-dependent effects of the novel antifolate pralatrexate and gemcitabine are superior to methotrexate and cytarabine in models of human non-Hodgkin's lymphoma. Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):924-32. PubMed PMID: 16467107. Samuels LL, Moccio DM, Sirotnak FM. Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro. Cancer Res. 1985 Apr;45(4):1488-95. PubMed PMID: 3978616. DeGraw JI, Christie PH, Kisliuk RL, Gaumont Y, Sirotnak FM. Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins. J Med Chem. 1990 Jan;33(1):212-5. PubMed PMID: 2296020.