TargetMol

RO27-3225 TFA (274682-89-2 free base)

Product Code:
 
TAR-TP2154
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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TAR-TP2154-100mg100mgEnquire
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TAR-TP2154-500mg500mgEnquire
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Further Information

Bioactivity:
RO27-3225 TFA is a potent and selective agonist of melanocortin 4 receptor (MC4R; EC50: 1 nM and 8 nM for MC4R and MC1R) with neuroprotective and anti-inflammatory effects. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R.
CAS:
TP2154
Molecular Weight:
898.93
Purity:
0.98

References

Zhang Y, et al. Effects of RO27-3225 on neurogenesis, PDGFR?+ cells and neuroinflammation after cerebral infarction. Int Immunopharmacol. 2020 Feb 11;81:106281. Benoit SC, et al. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci. 2000 May 1;20(9):3442-8. Giuliani D, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol. 2007 Mar;150(5):595-603.